Recharacterization of ancient DNA miscoding lesions: Insights in the era of the GS20
نویسندگان
چکیده
منابع مشابه
Recharacterization of ancient DNA miscoding lesions: insights in the era of sequencing-by-synthesis
Although ancient DNA (aDNA) miscoding lesions have been studied since the earliest days of the field, their nature remains a source of debate. A variety of conflicting hypotheses exist about which miscoding lesions constitute true aDNA damage as opposed to PCR polymerase amplification error. Furthermore, considerable disagreement and speculation exists on which specific damage events underlie o...
متن کاملNovel high-resolution characterization of ancient DNA reveals C > U-type base modification events as the sole cause of post mortem miscoding lesions
Ancient DNA (aDNA) research has long depended on the power of PCR to amplify trace amounts of surviving genetic material from preserved specimens. While PCR permits specific loci to be targeted and amplified, in many ways it can be intrinsically unsuited to damaged and degraded aDNA templates. PCR amplification of aDNA can produce highly-skewed distributions with significant contributions from ...
متن کاملInvestigating the Role of the Barmaki Family in the Transmission of Ancient Medical Knowledge to the Islamic Era (Hippocratic Medicine and Indian Medicine)
In the history of post-Islamic Iran, the Barmaki family is one of the most important families in preparing the background for the transfer of the scientific heritage of ancient times, including medical knowledge to the Islamic period. From the beginning of the Abbasid era, this family penetrated the structure of the political system and after gaining political-economic power and supporting tran...
متن کاملAssessing the fidelity of ancient DNA sequences amplified from nuclear genes.
To date, the field of ancient DNA has relied almost exclusively on mitochondrial DNA (mtDNA) sequences. However, a number of recent studies have reported the successful recovery of ancient nuclear DNA (nuDNA) sequences, thereby allowing the characterization of genetic loci directly involved in phenotypic traits of extinct taxa. It is well documented that postmortem damage in ancient mtDNA can l...
متن کاملTracks of ancient cosmetics in the modern era of cosmetics
Cosmetics is as old as the history of human being. It has been present in human life since the times of the most ancient civilizations. Perfumery is one of the oldest branches of cosmetics. Valerian perfumes found from the Pharaohs’ pyramids, had maintained their aroma. Coriander, Mace oil, cardamom, cinnamon, and juniper were also the favorite materials used for perfumery in ancient Egyptian c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008